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KMID : 0894319970060010163
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Dongguk Journal of the Institute of Oriental Medicine
1997 Volume.6 No. 1 p.163 ~ p.176
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The beneficial effect of Juglandis Semen extraction on oxidant-induced lung cell injury
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李佑憲/Lee, Woo-Heon
徐雲敎/鄭智天/Seo, Woon-Gyo/Jeong, Ji-Cheon
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Abstract
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This study was undertaken to determine whether Juglandis Semen extraction(JS) has a protective effect against the lung cell injury caused by oxidants, t-butylhydroperoxide(t-BHP) and H_(2)O_(2) in rabbit lung slices.
JS significantly prevented an increase in water content induced by t-BHP. Similarly, JS significantly prevented the lipid peroxidation induced by t-BHP. Cellular concentration of glutathione, and the activities of catalase and superoxide dismutase were significantly not altered by 5% JS. However, JS at 5% concentration significantly increased the glutathione peroxidase activity in oxidant-treated and control tissues. JS decreased directly the production of superoxide or hydroxyl radical.
These results indicate that JS prevents the cell injury and lipid peroxidation induced by oxidants in the lung. Such an antioxidant effect is attributed to enhancement of major endogenous antioxidant defence systems such as glutathione peroxidase and direct inhibition of oxygen free radical production.
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KEYWORD
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